The correlation of neutrophil-to-lymphocyte ratio (NLR) and monocytes-to-lymphocytes ratio (MLR) with disease severity in hospitalized patients with Coronavirus disease 2019 (COVID-19)

Background: Early intervention of cases with potential progression to severe disease is essential improve survival probability in Coronavirus 2019 (COVID-19). Systemic inflammation plays an role the process aggravation. This study aimed assess correlation systemic inflammatory response related biomarkers neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte (MLR) on time admission severity inpatients COVID-19.Methods: We performed a retrospective using secondary data from medical records COVID-19 at Murni Teguh Memorial Hospital, Medan, Indonesia, June 1 September 30, 2020. The demographic were collected record hematologic parameter laboratory. NLR MLR calculated by dividing absolute neutrophils monocytes counts lymphocyte counts. tabulated analyzed univariate bivariate analysis significance level p<0.05.Results: Study subjects consisted 55 non-severe 40 cases. median groups 7.65 vs 2.92 (p<0.001) 0.46 0.25 (p=0.013). coefficients 0.564 0.257 (p=0.012). AUC ROC was 0.830 (cut-off:>4.81;p<0.001) 0.650 (cut-off:>0.31; p=0.013) predict disease.Conclusion: had significant positive severity. better than predicting hospitalized patients COVID-19.